Tommi Kajander

21.2.2003
Institute of Biotechnology and Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki

Structural Evolution of Function and Stability in Muconate Lactonizing Enzymes

Reviewers:

Docent Sarah Butcher, Institute of Biotechnology, Department of Biosciences, University of Helsinki, Helsinki

Professor Juha Rouvinen, Department of Chemistry, University of Joensuu, Joensuu

Opponent:

Professsor Günter Schneider, Division of Structural Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

Custos:

Professor Adrian Goldman, Institute of Biotechnology, Research Program in Structural Biology and Biophysics, University of Helsinki, Helsinki

Publications:

  1. Schell U, Helin S, Schlömann M and Goldman A. (1999) Structural basis for the activity of two muconate lactonizing enzyme variant toward substituted muconates. Proteins. 34:125-136
  2. Kajander T, Kahn PC, Passila SH, Cohen DM, Lehtiö L, Adolfsen W, Warwicker J, Schell u AND Goldman A. (2000) Buried charged surface in proteins. Structure Fold Des. 8:1203-1214
  3. Merckel MC, Kajander T, Deacon AM, Thompson A, Grossman JG, Kalkkinen N and Goldman A. (2002) 3-carboxy-cis, cis-muconate lactonizing enzyme from neurospora crassa: MAD phasing with 80 seleniums. Acta Crystallogr. D58:727-734
  4. Kajander T, Merckel MC, Thompson A, Deacon AM, Mazur P, Kozarich JW and Goldman A. (2002) The structure of Neurospora crassa 3-carboxy-cis, cis-muconate lactonizing enzyme, a b propeller cycloisoerase. Structure. 10:483-492
  5. Kajander T, Lehtiö L and Goldman A. (2003) The structure of Pseudomonas P51 C1-muconate lactonizing enzyme - co-evalution of the hydrophobic core structure and dynamics with the dehalogenation (Manuscript).