Tommi Nyrönen

Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku and Center for Scientific Computing, Espoo

Properties and Recognition Mechanisms of Molecules - Targeting Design of New Receptor Ligands


Professor Matti Hotokka, Åbo Akademi University, Turku

Dr. Mikael Peräkylä, University of Kuopio, Kuopio


Professor Flemming Jorgensen, Royal Danish School of Pharmacy, Copenhagen, Denmark


Professor Mark S. Johnson, Department of Biohemistry and Pharmacy, Åbo Akademi University, Turku


  1. Nyrönen TH & Suontamo R. (1997). An ab initio MO study of neutral high symmetry C8 clusters. Chem. Phys. Letters 280:227-32.
  2. Airola K, Ratilainen J, Nyrönen T & Rissanen K. (1998). A linear open-chain piperazine-pyridine ligand and its meso-helical Co-complex. Inorganica Chim- ica Acta 277:55-61.
  3. Nyrönen TH, Suontamo R & Pitkänen I. (1999) Why betaine crystallizes in high local Cs symmetry. An ab initio MO and DFT study of anhydrous betaine and betaine monohydrate. Theoret. Chem. Accounts 101:209-14.
  4. Salminen T*, Varis M*, Nyrönen T, Pihlavisto M, Hoffren A-M, Lönnberg T, Marjamäki A, Frang H, Savola J-M, Scheinin M & Johnson MS. (1999) Three-dimensional models of a2A-adrenergic receptor complexes provide a structural explanation for ligand binding. J. Biol. Chem. 274:23405-13.
  5. Pentikäinen O, Hoffren A-M*, Ivaska J*, Käpylä J*, Nyrönen T*, Heino J & Johnson MS. (1999) "RKKH" Peptides from the snake venom metallopro- teinase of Bothrops jararaca bind near the metal ion-dependent adhesion site of the human integrin a2 I-domain. J. Biol. Chem. 274:31493-505.
  6. Nyrönen T, Pihlavisto M, Peltonen JM, Hoffren A-M, Varis M, Salminen T, Wurster S, Marjamäki A, Kanerva L, Laaksonen L, Savola J-M, Scheinin M & Johnson MS. (2001) Molecular mechanism for agonist promoted a2Aadrenoceptor activation by norepinephrine and epinephrine. Mol. Pharm., accepted.
* equal contributions