Shishir Jaikishan

28.09.2012

Department of Biosciences, Åbo Akademi University

Effects of methylation and hydroxylation of sphingomyelins on their biophysical properties and interactions with cholesterol.

Reviewers:

Dr. Marja T. Hyvönen, Department of Physics, University of Oulu, Oulu, Finland

Dr. Reijo Käkelä, Department of Biosciencesm University of Helsinki, Helsinki, Finland

Opponent:

Docent Pentti Somerharju, Institute of Biomedicine, Biochemistry, University of Helsinki, Helsinki, Finland

Custos:

Professor J. Peter Slotte, Department of Biosciences, Åbo Akademi University, Turku, Finland

Publications:

  1. Jaikishan S, Slotte JP. (2011) Effect of hydrophobic mismatch and interdigitation on sterol/sphingomyelin interaction in ternary bilayer membranes. Biochim Biophys Acta. 1808:1940-5
  2. Jaikishan S, Björkbom A, Slotte JP. (2010) Sphingomyelin analogs with branched N-acyl chains: the position of branching dramatically affects acyl chain order and sterol interactions in bilayer membranes. Biochim Biophys Acta. 1798:1987-94.
  3. Ekholm O, Jaikishan S, Lönnfors M, Nyholm TK, Slotte JP. (2011) Membrane bilayer properties of sphingomyelins with amide-linked 2- or 3-hydroxylated fatty acids. Biochim Biophys Acta. 1808:727-32.
  4. Jaikishan S, Slotte JP. (2012) Stabilization of sphingomyelin interactions by interfacial hydroxyls - A study of phytosphingomyelin properties. Biochim Biophys Acta. (in press)
  5. Björkbom A, Róg T, Kankaanpää P, Lindroos D, Kaszuba K, Kurita M, Yamaguchi S, Yamamoto T, Jaikishan S, Paavolainen L, Päivärinne J, Nyholm TK, Katsumura S, Vattulainen I, Slotte JP. (2011) N- and O-methylation of sphingomyelin markedly affects its membrane properties and interactions with cholesterol. Biochim Biophys Acta. 1808:1179-86.