Outi Salo

17.2.2006
Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio

Molecular modeling of the endogenous cannabinoid system

Reviewers:

Professor Patricia H. Reggio, Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, USA

Ph.D Anna-Marja Hoffrén, Adjunct Professor in Computer-Aided Drug Design, Fatman Bioinformational Designs Ltd., Turku

Opponent:

Dr. Hugo Kubinyi, Professor in Pharmaceutical Chemistry, University of Heidelberg, Germany

Custos:

Professor Antti Poso, Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio

Publications:

  1. Salo OMH, Lahtela-Kakkonen M, Gynther J, Järvinen T & Poso A. (2004) Development of a 3D Model for the Human Cannabinoid CB1 Receptor. J Med Chem. 47:3048-3057.
  2. Saario MS, Salo OMH, Nevalainen T, Poso A, Laitinen JT, Järvinen T, Niemi R. (2005) Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chemistry & Biology. 12:649-656.
  3. Salo OMH, Raitio KH, Savinainen JR, Nevalainen T, Lahtela-Kakkonen M, Laitinen JT, Järvinen T & Poso A. (2005) Virtual screening of novel CB2 ligands using a comparative model of the CB2 receptor. J Med Chem. 48:7166-71.
  4. Salo OMH, Savinainen JR, Parkkari T, Nevalainen T, Lahtela-Kakkonen M, Gynther J, Laitinen JT, Järvinen T & Poso A. (2006) 3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data. J Med Chem. 49:554-66.