Outi Koskela

18.12.2009
Institute of Biotechnology, University of Helsinki

NMR Spectroscopy of Multi-domain Proteins : Immunoglobulin-like Domains of Human Filamin A

Reviewers:

Professor Johanna Ivaska, VTT Technial Research Centre of Finland, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Department of Biochemistry and Food Chemistry, University of Turku, Finland

Professor Arto Annila, Department of Biosciences and Institute of Biotechnology, University of Helsinki, Finland

Opponent:

Professor Stephan Grzesiek, Division of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland

Publications:

  1. Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpeläinen I, Munday AD, Hartwig JH, Stossel TP, Ylänne J. (2006) The structure of the GPIb-filamin A complex. Blood 107:1925-1932.
  2. Nakamura F, Heikkinen O, Pentikäinen OT, Osborn TM, Kasza KE, Weitz DA, Kupiainen O, Permi P, Kilpeläinen I, Ylänne J, Hartwig JH, Stossel TP. (2009). Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations. PLoS One. 4:e4928.
  3. Heikkinen O, Permi P, Koskela H, Ylänne J, Kilpeläinen I. (2009) 1H, 13C and 15N resonance assignments of the human filamin A tandem immunoglobulin-like domains 16-17 and 18-19. Biomol NMR Assign. 2009 Jun;3(1):53-6.
  4. Heikkinen OK, Ruskamo S, Konarev PV, Svergun DI, Iivanainen T, Heikkinen SM, Permi P, Koskela H, Kilpeläinen I, Ylänne J. (2009) Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin. The Journal of Biological Chemistry 284:25450-8.
  5. Koskela O, Permi P, Jiang P, Campbell ID, Ylänne J, Kilpeläinen I. Protein domain organization studies using residual dipolar couplings; Filamin A immunoglobulin-like domains 16-21. (Manuscript).