Mohit Narwal

28.03.2014
Pharmaceutical Sciences, Department of Biosciences, Åbo Akademi University

Selective Inhibition of Human Tankyrases

Reviewers:

Docent Tommi Kajander, Institute of Biotechnology, University of Helsinki, Helsinki, Finland

Dr. Jens Preben Morth, Center for Molecular Medicine, University of Oslo, Oslo, Norway

Opponent:

Associate Professor Herwig Schüler, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Custos:

Docent Adyary Fallarero, Department of Biosciences, Åbo Akademi University, Turku, Finland

Publications:

  1. Narwal M, Fallarero A, Vuorela P, Lehtiö L (2012) Homogeneous screening assay for human tankyrase. J Biomol Screen. 17(5):593-604
  2. Narwal M, Venkannagari H, Lehtiö L (2012) Structural basis of selective inhibition of human tankyrases. J Med Chem. 55(3):1360-1367
  3. Narwal M, Haikarainen T, Fallarero A, Vuorela PM, Lehtiö L (2013) Screening and structural analysis of flavones inhibiting tankyrases. J Med Chem. 56(9):3507-17
  4. Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtiö L (2013) Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 56(20):7880-7889
  5. Haikarainen T*, Narwal M*, Joensuu P, Lehtiö L (2013) Evaluation and structural basis for the inhibition of tankyrases by PARP inhibitors. ACS Med Chem. Lett. 5(1):18-22
* Equal contribution.