Mirko Maksimainen

16.11.2012

Department of Chemistry, University of Eastern Finland, Joensuu Campus, Joensuu, Finland

Structural studies of Trichoderma reesei, Aspergillus oryzae and Bacillus circulans sp. alkalophilus beta-galactosidases - Novel insights into a structure-function relationship

Reviewers:

Docent Tiina A Salminen, Department of Biosciences, Åbo Akademi University, Turku, Finland

Dr. Anu Koivula, VTT Technical Research Centre of Finland, Helsinki, Finland

Opponent:

Professor Professor Markku Kulomaa, IBT, University of Tampere, Tampere, Finland

Custos:

Professor Juha Rouvinen, Department of Chemistry, University of Eastern Finland, Joensuu Campus, Joensuu, Finland

Publications:

  1. Maksimainen M, Timoharju T, Kallio JM, Hakulinen N, Turunen O, Rouvinen J. (2009) Crystallization and preliminary diffraction analysis of a beta-galactosidase from Trichoderma reesei. Acta Crystallogr Sect F Struct Biol Cryst Commun. 65: 767-769.
  2. Maksimainen M, Hakulinen N, Kallio JM, Timoharju T, Turunen O, Rouvinen J. (2011) Crystal structures of Trichoderma reesei beta-galactosidase reveal conformational changes in the active site. J Struct Biol. 174:156-163
  3. Maksimainen M, Paavilainen S, Hakulinen N, Rouvinen J. (2012) Structural analysis, enzymatic characterization, and catalytic mechanisms of beta-galactosidase from Bacillus circulans sp. alkalophilus. FEBS J. 279:1788-1798
  4. Maksimainen M, Lampio A, Mertanen M, Turunen O, Rouvinen J. Crystal structure of acidic beta-galactosidase from Aspergillus oryzae. (Submitted)