Mira Tulla

2.2.2007
Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä

Collagen receptor integrins: evolution, ligand binding selectivity and the effect of activation

Reviewers:

Docent Johanna Myllyharju, PhD., Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu

Professor Markku Kulomaa, Institute of Medical Technology, University of Tampere, Tampere

Opponent:

Professor Carl G. Gahmberg, Department of Biological and Environmental Sciences, University of Helsinki, Helsinki

Custos:

Professor Jari Ylänne, Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä

Publications:

  1. Tulla M, Pentikäinen OT, Viitasalo T, Käpylä J, Impola U, Nykvist P, Nissinen L, Johnson MS & Heino J. (2001) Selective binding of collagen subtypes by integrin alpha 1I, alpha 2I and alpha 10I domains. J. Biol. Chem. 276:48206-48212.
  2. Käpylä J, Jäälinoja J, Tulla M, Ylöstalo J, Nissinen L, Viitasalo T, Vehviläinen P, Marjomäki V, Nykvist P, Saamanen AM, Farndale RW, Birk DE, Ala-Kokko L & Heino J. (2004) The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix. J Biol Chem 279:51677-87.
  3. Tulla M, Lahti MJ, Puranen JS, Brandt A-M, Burcza A, Käpylä J, Salminen TA, Johnson MS & Heino J. (2006) Integrin activation decreases the selectivity of α2I domain for collagen subtypes but is prerequisite for laminin binding. Manuscript
  4. Tulla M, Huhtala M, Jäälinoja J, Käpylä J, Farndale RW, Ala-Kokko L, Johnson MS & Heino J. (2006) Analysis of an ascidian integrin provides new insights into early evolution of collagen recognition. Manuscript