Luca Settimo

02.09.2005
Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku

Structural basis for ligand recognition in the ionotropic glutamate receptors

Reviewers:

Professor Esa Korpi, Department of Pharmacology, University of Helsinki, Helsinki

Dr. Pekka Lehtovuori, Center for Scientific Computing, Espoo

Opponent:

Professor Jan Egebjerg, Department of Molecular Biology, University of Aarhus, Denmark

Custos:

Professor Mark S. Johnson, Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku

Publications:

  1. Lampinen M, Settimo L, Pentikäinen OT, Jouppila A, Mottershead DG, Johnson MS & Keinänen K. (2002). Discrimination between agonists and antagonists by the a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid - selective glutamate receptor. A mutation analysis of the ligand-binding domain of GluR-D subunit . J Biol Chem. 277:41940-41947.
  2. Jouppila A, Pentikäinen OT, Settimo L, Nyrönen T, Haapalahti JP, Lampinen M, Mottershead DG, Johnson MS & Keinänen K (2002) Determinants of antagonist binding at the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR-D: Role of the conserved Arg-507 and Glu-727 residues. Eur J Biochem. 269: 6261-6270
  3. Pentikäinen OT, Settimo L, Keinšänen K & Johnson MS. (2003) Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2-alpha,3-beta,4-beta)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacidic acid (kainate) receptors: a molecular modeling study. Biochemical Pharmacology. 66:2413-2425.
  4. Moretti L, Pentikäinen OT, Settimo L & Johnson MS. (2004) Model structures of the N-methyl-d-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands. J. Struc. Biol. 145:205-215.
  5. Settimo L*, Pentikäinen U*, Johnson MS & Pentikäinen OT. Subtype selectivity and flexibility of ionotropic glutamate receptors upon antagonist ligand binding (submitted).
  6. Sanders JM, Ito K, Settimo L, Pentikäinen OT, Shoji M, Sasaki M, Johnson MS, Sakai R & Swanson GT. (2005) Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors. J Pharmacol Exp Ther. 314:1068-78. * equal contribution to the work