Juha Määttä

Institute of Medical Technology (IMT), University of Tampere

Structural and Functional Characterization of Engineered Avidin Proteins


Professor Reijo Lahti, Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

Professor Antti Poso, Department of Pharmacy, University of Eastern Finland, Kuopio, Finland


Professor Pirkko Heikinheimo, Institute of Biotechnology University of Helsinki, Helsinki, Finland


Professor Markku Kulomaa, IMT, University of Tampere, Tampere, Finland


  1. Hytönen VP, Määttä JA, Nyholm TK, Livnah O, Eisenberg-Domovich Y, Hyre D, Nordlund HR, Hörhä J, Niskanen EA, Paldanius T, Kulomaa T, Porkka EJ, Stayton PS, Laitinen OH & Kulomaa MS. (2005) Design and construction of highly stable, protease-resistant chimeric avidins. J Biol Chem. Mar 18;280(11):10228-33.
  2. Hytönen VP, Määttä JA, Niskanen EA, Huuskonen J, Helttunen KJ, Halling KK, Nordlund HR, Rissanen K, Johnson MS, Salminen TA, Kulomaa MS, Laitinen OH & Airenne TT. (2007) Structure and characterization of a novel chicken biotin-binding protein A (BBP-A). BMC Struct Biol. 2007 Mar 7;7:8.
  3. Määttä JA, Airenne TT, Nordlund HR, Jänis J, Paldanius TA, Vainiotalo P, Johnson MS, Kulomaa MS, Hytönen VP. (2008) Rational modification of ligand-binding preference of avidin by circular permutation and mutagenesis. Chembiochem. 2008 May 5;9(7):1124-35.
  4. Määttä JA, Eisenberg-Domovich Y, Nordlund HR, Hayouka R, Kulomaa MS, Livnah O, Hytönen VP, (2010) Chimeric vidin shows good stability in hars chemical conditions - Biochemical analysis and 3D structure. (submitted)