Jiong Cao

18.05.2005
Department of Neurobiology, Faculty of Medicine, University of Kuopio, Kuopio

The regulation and role of stress-activated protein kinases (p38 and JNK) in neuronal cell death

Reviewers:

Professor Kari Keinänen, Department of Biological and Environmental Sciences, University of Helsinki, Helsinki

Docent Tuula Kallunki, Apoptosis Laboratory, Institute for Cancer Biology, Danish Cancer Society, Copenhagen, Denmark

Opponent:

Professor Jochen H.M. Prehn, Royal College of Surgeons in Ireland, Dublin, Ireland

Custos:

Docent Michael Courtney, Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio

Publications:

  1. Coffey ET, Smiciene G, Hongisto V, Cao J, Brecht S, Herdegen Tv & Courtney MJ. (2002) JNK2/3 is specifically activated by stress, mediating c-jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons. J Neurosci. 22:4335-4345.
  2. Cao J, Semenova MM, Solovyan VT, Han J, Coffey ET & Courtney MJ. (2004) Distinct requirements for p38-alpha and JNK stress-activated protein kinases in different forms of apoptotic neuronal death. J Biol Chem. 279(34):35903-35913.
  3. Cao J, Viholainen JI, Dart C, Warwick HK, Leyland ML & Courtney MJ.(2005) The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. J Cell Biol. 168:117-126.
  4. Cao J, Semenova MM, Courtney MJ. (2005) Rho mediates calcium-dependent activation of p38-alpha and subsequent excitoxic cell death. (submitted)