Jiong Cao

Department of Neurobiology, Faculty of Medicine, University of Kuopio, Kuopio

The regulation and role of stress-activated protein kinases (p38 and JNK) in neuronal cell death


Professor Kari Keinänen, Department of Biological and Environmental Sciences, University of Helsinki, Helsinki

Docent Tuula Kallunki, Apoptosis Laboratory, Institute for Cancer Biology, Danish Cancer Society, Copenhagen, Denmark


Professor Jochen H.M. Prehn, Royal College of Surgeons in Ireland, Dublin, Ireland


Docent Michael Courtney, Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio


  1. Coffey ET, Smiciene G, Hongisto V, Cao J, Brecht S, Herdegen Tv & Courtney MJ. (2002) JNK2/3 is specifically activated by stress, mediating c-jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons. J Neurosci. 22:4335-4345.
  2. Cao J, Semenova MM, Solovyan VT, Han J, Coffey ET & Courtney MJ. (2004) Distinct requirements for p38-alpha and JNK stress-activated protein kinases in different forms of apoptotic neuronal death. J Biol Chem. 279(34):35903-35913.
  3. Cao J, Viholainen JI, Dart C, Warwick HK, Leyland ML & Courtney MJ.(2005) The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. J Cell Biol. 168:117-126.
  4. Cao J, Semenova MM, Courtney MJ. (2005) Rho mediates calcium-dependent activation of p38-alpha and subsequent excitoxic cell death. (submitted)