Henri Xhaard

Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku

Adrenoceptors: Evolution, Structure Modeling and Ligand Recognition


Professor Reijo Lahti, Department of Biochemistry, University of Turku, Turku

Professor Antti Poso, Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio


Professor Marcel Hibert, Département de Pharmacochimie de la Communication Cellulaire, Institut Gilbert Laustriat, Faculté de Pharmacie de Strasbourg, Illkirch, France


Professor Mark S. Johnson, Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku


  1. Ruuskanen J, Xhaard H, Marjamäki A, Salaneck E, Salminen T, Yan Y-L, Postlethwait JH, Johnson MS, Larhammar D & Scheinin M. (2004) Identification of duplicated fourth alpha-2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol. Biol. Evol. 21:14-28.
  2. Ruuskanen JO, Laurila J, Xhaard H, Rantanen V-V, Vuoriluoto K, Wurster S, Marjamäki A, Vainio M, Johnson MS & Scheinin M. (2005) Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha-2-adrenergic receptors. Brit J Pharm. 144:165-177.
  3. Xhaard H, Nyrönen T, Rantanen V-V, Ruuskanen J O, Laurila J, Salminen T, Scheinin M, and Johnson M S. (2005) Model structures of alpha-2 adrenoceptors in complex with automatically docked antagonist ligands raise the possibility of interactions dissimilar from agonist ligands. J Struct Biol. 150:126-143.
  4. Xhaard H, Rantanen V-V, Nyrönen T and Johnson M S. (2006) Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines. J Med Chem. 49: 1706-1719.