Heikki Takala

Department of Biologial and Envirmonmental Sciences, University of Jyväskylä, Jyväskylä, Finland

Three Proteins Regulating Integrin Function - Filamin, 14-3-3 and RIAM


Professor Jyrki Heino, Department of Biochemistry and Food Chemistry, Turku, Finland

Assistant Professor Inari Kursula, Centre for Structural Systems Biology at DESY; Helmholtz Centre for Infection Research and University of Hamburg Hamburg, Germany and Department of Biochemistry, University of Oulu, Oulu, Finland


Associate Professor David A. Calderwood, Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA


Professor Jari Ylänne, Department of Biologial and Environmental Sciences, University of Jyväskylä, Jyväskylä, Finland


  1. Takala H. & Ylänne J. (2011) Binding Properties and Stability of the Rasassociation Domain of Rap1-GTP Interacting Adapter Molecule (RIAM). (Submitted)
  2. Pentikäinen U, Jiang P, Takala H, Ruskamo S, Campbell ID & Ylänne J. (2011) Assembly of a Filamin Four-domain Fragment and the Influence of Splicing Variant-1 on the Structure. Journal of Biological Chemistry 286: 26921-26930.
  3. Takala H,* Nurminen E,* Nurmi SM,* Aatonen M, Strandin T, Takatalo M, Kiema T, Gahmberg CG, Ylänne J & Fagerholm SC. (2008) Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding. Blood 112: 1853-1862.
* Equal contribution