Heikki Käsnänen

07.06.2014
School of Pharmacy, University of Eastern Finland, Kuopio Campus

Endocannabinoid hydrolyzing enzymes: Molecular modelling and computer-aaided inhibitor discovery

Reviewers:

Professor Frank M. Böckler, Pharmazeutisches Institut, Eberhard Karls Universität Tübingen, Tübingen, Germany

Docent, Tommi Nyrönen, CSC - IT Center for Science, Espoo, Finland

Opponent:

Professor Thierry Langer, Department of Life Sciences, University of Vienna, Vienna, Austria

Custos:

Professor Antti Poso, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

Publications:

  1. Myllymäki MJ, Käsnänen H, Kataja AO, Lahtela-Kakkonen M, Saario SM, Poso A, Koskinen AM. (2009) Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields. Eur J Med Chem. 44:4179-4191
  2. Käsnänen H*, Myllymäki MJ*, Minkkilä A*, Kataja AO, Saario SM, Nevalainen T, Koskinen AM, Poso A. (2010) 3-Heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: design, synthesis and 3D-QSAR studies. ChemMedChem. 5:213-231
  3. Minkkilä A, Saario SM, Käsnänen H, Leppänen J, Poso A, Nevalainen T. (2008) Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 51:7057-7060
  4. Minkkilä A, Savinainen JR, Käsnänen H, Xhaard H, Nevalainen T, Laitinen JT, Poso A, Leppänen J, Saario SM. (2009) Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors. ChemMedChem. 4:1253-1259
  5. Käsnänen H*, Minkkilä A*, Taupila S, Patel JZ, Parkkari T, Lahtela-Kakkonen M, Saario SM, Nevalainen T, Poso A. (2013) 1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling. Eur J Pharm Sci. 49:423-433
* Equal contribution.