Heikki Käsnänen

School of Pharmacy, University of Eastern Finland, Kuopio Campus

Endocannabinoid hydrolyzing enzymes: Molecular modelling and computer-aaided inhibitor discovery


Professor Frank M. Böckler, Pharmazeutisches Institut, Eberhard Karls Universität Tübingen, Tübingen, Germany

Docent, Tommi Nyrönen, CSC - IT Center for Science, Espoo, Finland


Professor Thierry Langer, Department of Life Sciences, University of Vienna, Vienna, Austria


Professor Antti Poso, School of Pharmacy, University of Eastern Finland, Kuopio, Finland


  1. Myllymäki MJ, Käsnänen H, Kataja AO, Lahtela-Kakkonen M, Saario SM, Poso A, Koskinen AM. (2009) Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields. Eur J Med Chem. 44:4179-4191
  2. Käsnänen H*, Myllymäki MJ*, Minkkilä A*, Kataja AO, Saario SM, Nevalainen T, Koskinen AM, Poso A. (2010) 3-Heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: design, synthesis and 3D-QSAR studies. ChemMedChem. 5:213-231
  3. Minkkilä A, Saario SM, Käsnänen H, Leppänen J, Poso A, Nevalainen T. (2008) Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 51:7057-7060
  4. Minkkilä A, Savinainen JR, Käsnänen H, Xhaard H, Nevalainen T, Laitinen JT, Poso A, Leppänen J, Saario SM. (2009) Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors. ChemMedChem. 4:1253-1259
  5. Käsnänen H*, Minkkilä A*, Taupila S, Patel JZ, Parkkari T, Lahtela-Kakkonen M, Saario SM, Nevalainen T, Poso A. (2013) 1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling. Eur J Pharm Sci. 49:423-433
* Equal contribution.