Georgiy Belogurov

Department of Biochemistry and Food Chemistry, University of Turku, Turku

Pyrophosphate-energized proton pumps: identification of the residues determining K+ requirements and discovery of a Na+-dependent enzyme


Professor Mark S Johnson, Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku, Finland

Professor Simo Laakso, Department of Chemical Technology, Helsinki University of Technology, Helsinki, Finland


Professor J. Baz Jackson, School of Biosciences, University of Birmingham, Birmingham, U.K.


Professor Reijo Lahti, Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland


  1. Belogurov GA, Turkina MV, Penttinen A, Vanhatalo S, Baykov AA & Lahti R. (2002) H+-pyrophosphatase of Rhodospirillum rubrum: High-yield expression in Escherichia coli and identification of the cys residues responsible for inactivation by mersalyl. J Biol Chem. 277: 22209-22214.
  2. Belogurov GA & Lahti R. (2002) A Lysine Substitute for K+. A460K mutation elilminates K+ dependence in H+ -pyrophosphatase of Carboxydothermus hydrogenoformans. J Biol Chem 277:49651-49654.
  3. Malinen AM, Belogurov GA, Salminen M, Baykov AA. & Lahti R. (2004) Elucidating the role of conserved glutamates in H+-pyrophosphatase of Rhodospirillum rubrum. J. Biol. Chem. 279: 26811-26816.
  4. Belogurov GA, Malinen AM, Turkina MV, Jalonen U, Rytkönen K, Baykov AA & Lahti R. Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity. Biochemistry (under revision).