Denis Kainov

Department of Biological and Environmental Sciences, University of Helsinki, Helsinki

Packaging Motors of Cystoviruses


Docent Mikko Frilander, University of Helsinki, Helsinki

Docent Alexander Plyusnin, University of Helsinki, Helsinki


Professor John Walker, Medical Research Council, Dunn Human Nutrition Unit, Cambridge, United Kingdom


Professor Tapio Palva, University of Helsinki, Helsinki


  1. Kainov DE, Butcher SJ, Bamford DH & Tuma R. (2003) Conserved intermediates on the assembly pathway of dsRNA bacteriophages. J. Mol. Biol. 328:791-804.
  2. Kainov DE, Pirttimaa M, Tuma R, Butcher SJ, Thomas GJ, Bamford DH & Makeyev EV. (2003) RNA packaging device of dsRNA bakteriophages: Possibly as simple as hexamer of P4 protein. J. Biol. Chem. 278:48084-48091.
  3. Kainov DE, Lísal J, Bamford DH & Tuma R. (2004) Packaging motor from double-stranded RNA bacteriophage phi12 acts as an obligatory passive conduit during transcription. Nucl Acid Res 32:3515-21.
  4. Mancini EJ, Kainov DE, Grimes JM, Tuma R, Bamford DH & Stuart DI. (2004) Atomic Snapshots of an RNA Packaging Motor Reveal Conformational Changes Linking ATP Hydrolysis to RNA Translocation. Cell 118:743-755.
  5. Lísal J, Lam T, Kainov DE, Emmett MR, Marshall AG & Tuma R. (2005) Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states. Nat. Struct. Mol. Biol. 12: 460-466.
  6. Kainov DE, Mancini EJ, Lisal J, Grimes JM, Bamford DH, Stuart DI & Tuma R. (2005) Structural basis of mechanochemical coupling in hexameric packaging motors. Manuscript.