Daniela Karlsson

20.11.2013
Department of Biosciences, Åbo Akademi University

Biomolecular Screening for Inhibitors of Butyrylcholinesterase: Identification and characterization using in vitro and in silico tools.

Reviewers:

Professor Jari Yli-Kauhaluoma, Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Professor Raimo Tuominen, Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Opponent:

Professor Anders Backlund, Division of Pharmacognosy, Department of Medical Chemistry, Uppsala University, Uppsala, Sweden

Custos:

Docent Adyary Fallarero, Department of Biosciences, Åbo Akademi University, Turku, Finland

Publications:

  1. Karlsson D, Fallarero A, Brunhofer G, Guzik P, Prinz M, Holzgrabe U, Erker T, Vuorela P. (2012) Identification and characterization of diarylimidazoles as hybrid inhibitors of butyrylcholinesterase and amyloid beta fibril formation. Eur J Pharm Sci. 45(1-2):169-183.
  2. Karlsson D, Fallarero A, Brunhofer G, Mayer C, Prakash O, Mohan CG, Vuorela P, Erker T. (2012) The exploration of thienothiazines as selective butyrylcholinesterase inhibitors. Eur J Pharm Sci. 30;47(1):190-205.
  3. Brunhofer G, Fallarero A, Karlsson D, Batista-Gonzalez A, Shinde P, Gopi Mohan C, Vuorela P. (2012) Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorg Med Chem. 22:6669-6679.
  4. Karlsson D, Fallarero A, Shinde p, Anju CP, Busygin I, Leino R, Mohan CG, Vuorela P. Chemical modifications of cinchona alkaloids lead to enchanced inhibition of human butyryl chol ines terase (Submitted)