Annamari Paino

Department of Biochemistry, University of Turku

Virulence properties of Aggregatibacter actinomycetemcomitans biofilm and characterisation of its putative cytokine exploitation


Associate Professor Georgios Belibasakis, DDS, Ph.D. Section of Oral Microbiology and Immunology, Institute of Oral Biology University of Zurich, Switzerland

Docent Pirkko Pussinen, Ph.D., Institute of Dentistry, University of Helsinki, Helsinki, Finland


Professor Mikael Rhen, Ph.D. Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Sweden

Supervised by

Docent Riikka Ihalin, Ph.D. Department of Biochemistry, University of Turku, Turku, Finland

Marja Pöllänen, DDS, Ph.D. Department of Periodontology, Institute of Dentistry University of Turku, Turku, Finland


Professor Jyrki Heino, Department of Biochemistry, University of Turku, Turku, Finland


  1. Paino A, Tuominen H, Jääskeläinen M, Alanko J, Nuutila J, Asikainen SE, Pelliniemi LJ, Pöllänen MT, Chen C, Ihalin R. (2011) Trimeric form of intracellular ATP synthase subunit β of Aggregatibacter actinomycetemcomitans binds human interleukin-1β. PLoS One. 6(4):e18929.
  2. Paino A, Lohermaa E, Sormunen R, Tuominen H, Korhonen J, Pöllänen MT, Ihalin R. (2012) Interleukin-1β is internalised by viable Aggregatibacter actinomycetemcomitans biofilm and locates to the outer edges of nucleoids. Cytokine. 60(2):565-74
  3. Paino A, Ahlstrand T, Nuutila J, Navickaite I, Lahti M, Tuominen H, Välimaa H, Lamminmäki U, Pöllänen MT, Ihalin R. (2013) Identification of a novel bacterial outer membrane interleukin-1Β-binding protein from Aggregatibacter actinomycetemcomitans. PLoS One. 8(7):e70509
  4. Tarry M, Jääskeläinen M, Paino A, Tuominen H, Ihalin R, Högbom M. (2011) The extra-membranous domains of the competence protein HofQ show DNA binding, flexibility and a shared fold with type I KH domains. J Mol Biol. 409(4):642-53