Hideo Iwai, Ph.D., Adjunct Professor
Institute of Biotechnology
University of Helsinki
NMR-laboratory Biocenter 3
PO Box 65, FI-00014 Helsinki Phone:+358-9-191-59752
Fax: +358-9-191-59541
http://www.biocenter.helsinki.fi/bi/iwai/
Graduate students:

My research focuses on elucidation of structure-function relationship of proteins using protein engineering and NMR spectroscopy. Recently we have been working on development of new protein-engineering tools using protein splicing domains for structural biology. NMR spectroscopy can provide not only three-dimensional structures of proteins but also additional information about proteins at atomic resolution such as protein dynamics and pKa of active sites. Non-invasive NMR spectroscopy can be applied to studies of protein structures in living cells. We are trying to understand protein structure-function relationships in living systems by combining NMR spectroscopy and protein engineering techniques.