National Doctoral Programme in
Informational and Structural Biology

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Publications 2003

• Airenne KJ, Peltomaa E, Hytönen VP, Laitinen OH, Ylä-Herttuala S. (2003) Improved generation of recombinant baculovirus genomes in Escherichia coli. Nucleic Acids Res. 31, Vol. 17:e101.
• Aittokallio T, Kurki M, Nikula T, West A, Lahesmaa R & Nevalainen O. (2003) Computational strategies for analyzing data in gene expression microarray experiments. J. Bioinformatics and Computational Biology 3:541-586.
• Asikainen A, Tarhanen J, Poso A, Pasanen M, Alhava E & Juvonen RO. (2003) Predictive value of Comparative Molecular Field Analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes. Toxicology in Vitro. 17:449-455.
• Bartus CL, Jaakola V-P, Reusch R, Valentine HH, Heikinheimo P, Levy A, Potter LT, Heimo H, Goldman A & Turner GJ. (2003) Downstream coding region determinants of bacterio-opsin, muscarinic acetylcholine receptor and adrenergic receptor expression in Halobacterium salinarum. Biochim Biophys Acta 1610(1):109-123.
• Burke M, O'Sullivan PJ, Soini AE, Berney H & Papkovsky DB. (2003) Evaluation of the phosphorescent palladium(II)-coproporphyrin labels in separation-free hybridization assays. Analytical Biochemistry 320:273-280.
• Casas S, Ollila J, Aventin A, Vihinen M, Sierra J & Knuutila S. (2003) Changes in apoptosis-related pathways in acute myelocytic leukemia. Cancer Genet Cytogenet 146:89-101.
• Chavali GB, Papageorgiou AC, Olson KA, Fett JW, Hu GF, ShapiroR & Acharya KR. (2003) The crystal structure of human angiogenin in complex with an antitumor neutralizing antibody. Structure. 11:875-885.
• Chen Z, Lund R, Aittokallio T, Nevalainen O & Lahesmaa R. (2003) Identification of early, positively and negatively regulated targets of STAT6 in IL-4 stimulated CD4+ T lymphocytes induced to polarize to Th2 cells. J Immunol. 171:3627-3635.
• Coleman SK, Cai C, Haapalahti JP, Mottershead DG & Keinänen K. (2003) Surface expression of GluR-D AMPA receptor is dependent upon an interaction between its C-terminal domain and a 4.1 protein. J. Neurosci. 23:798-806.
• Denesyuk AI, Denessiouk KA, Korpela T & Johnson MS. (2003) Phosphate group binding "cup" of PLP-dependent and non-PLP-dependent enzymes: leitmotif and variations. Biochim. Biophys. Acta. 1647:234-8.
• Denessiouk K & Johnson MS. (2003) "Acceptor-Donor-Acceptor" motifs recognize the Watson-Crick, Hoogsteen and Sugar "Donor-Acceptor-Donor" edges of adenine and adenosine containing ligands. J. Mol. Biol. 333:1025-1043.
• Denessiouk K & Johnson MS. (2003) Rules for ligand recognition by proteins: Nucleotide recognition in ATP-, NAD-, NADP- and FAD-dependent proteins with different fold. In: Protein structures: Kaleidoscope of Structural Properties and Function. Pp. 49-72.
• Doan D, Lee KC, Laurinmäki P, Butcher SJ, Wong S & Dokland T. (2003) Three-dimensional reconstruction of Hibiscus chlorotic ringspot virus. J. Struct. Biol. 144:253-261
• Dubnovitsky AP, Kapetaniou EG & Papageorgiou AC. (2003) Expression, purification, crystallization and preliminary crystallographic analysis of phosphoserine aminotransferase from Bacillus alcalophilus. Acta Crystallogr D Biol Crystallogr. 59:2319-21.
• Fraunberg Mvuz, Nyrönen T & Kauppinen R. (2003) Mitochondrial Targeting of Normal and Mutant Protoporphyrinogen Oxidase, Journal of Biological Chemistry 278:13376-13381.
• Gonzalez MM, Samenfeld P, Peräkylä M ∓ Carlberg C. (2003) Corepressor excess shifts the two side chain vitamin D analogue gemini from an agonist to an inverse agonist of the vitamin D receptor. Mol. Endocrinol. 17:2028-2038.
• Gordon K, Redelinghuys P, Schwager SLU, Ehlers MRW, Papageorgiou AC, Natesh R, Acharya KR & Sturrock ED. (2003) Deglycosylation, processing and crystallisation of human testis angiotensin-converting enzyme. Biochem. J. 371:437-442.
• Gröhn M & Nyrönen T. (2003) Integration and Utilization of Different Visualization Methods and Devices in a Structure-Based Drug Design Process, Proc. SPIE, Santa Clara, California Vol. 5009 pp. 11-18.
• Hakulinen N, Turunen O, Jänis J, Leisola M & Rouvinen J. Three-dimensional structures of thermophilic beta-1,4-xylanases from Chaetomium thermophilum and Nonomuraea flexuosa. Eur. J. Biochem. 270 (2003) 1399-1412.
• Haruyama T, Bongsebandhu-Phubhakdi S, Nakamura I, Mottershead D, Keinänen K, Kobatake E & Aizawa M. (2003) A novel biosensing system based on extracellular potential recording of ligand-gated ion channel function - overexpressed in insect cells. Anal. Chem.75:918-921.
• Hashizume H, Hämäläinen H, Sun Q, Sucharczuk A & Lahesmaa R (2003) A novel human mafB oncogene encodes for a bZip domain and is differentially expressed in human Th1 and Th2 cells. Scand J Immunol. 57:28-34.
• Heger A & Holm L. (2003) Sensitive pattern discovery with 'fuzzy' alignments of distantly related proteins. Bioinformatics 19 Suppl. 1, i130-i137.
• Heger A & Holm L. (2003) More for less in structural genomics. J Struct Func Genomics 4(2-3):57-66.
• Heikinheimo P, Helland R., Leiros H-KS, Ingar L, Karlsen S, Evjen G, Ravelli R, Schoehn G, Ruigrok R, Tollersrud O-K, McSweeney S & Hough E. (2003) The structure of bovine lysosomal alfa-mannosidasesuggests a novel mechanism for low pH activation. Journal of Molecular Biology 327:631-644.
• Heikinheimo P, Helland R, Leiros H-KS, Leiros I, Karlsen S, Evjen, G, Ravelli R, Schoehn G, Ruigrok R, Tollersrud O-K, McSweeney S & Hough E. (2003) Structure of the Bovine Lysosomal alfa-mannosidase, the Enzyme Involved in the Lysosomal Storage Disease alfa-Mannosidosis. ESRF Highlights 2002, 12-13.
• Hirvonen M. & Papageorgiou AC. (2003) Crystal structure of a family 45 endoglucanase from Melanocarpus albomyces: Mechanistic implications based on the free and cellobiose-bound forms. J. Mol. Biol. 329:403-410.
• Hongisto V, Smeds N, Brecht S, Herdegen T, Courtney MJ & Coffey ET. (2003) Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3. Mol. Cell.Biol. 23:6027-6036.
• Huiskonen JT, Laakkonen L, Toropainen M, Sarvas M, Bamford DH & Bamford JK. (2003). Probing the ability of the coat and vertex protein of the membrane-containing bacteriophage PRD1 to display a meningococcal epitope. Virology 310:267-79
• Hynes J, Floyd S, Soini AE, O'Connor R & Papkovsky DB. (2003) Fluorescence-based cell viability screening assays using water-soluble oxygen probes. Journal of Biomolecular Screening 8:264-272.
• Hytönen VP, Laitinen OH, Grapputo A, Kettunen A, Savolainen J, Kalkkinen N, Marttila AT, Nordlund HR, Nyholm TK, Paganelli G & Kulomaa MS. (2003) Characterization of poultry egg-white avidins and their potential as a tools in pretargeting cancer treatment. Biochem J. 372:219-25.
• Hämäläinen H & Lahesmaa R. (2003) Mikrosiruteknologiat - biologisia mittauksia miniatyyrikoossa. Suomen Lääkärilehti, 20:2195-2200.
• Hänninen P, Waris M, Kettunen M & Soini E. (2003) Reaction kinetics of a two-photon excitation microparticle based immunoassay from modelling to practice. Biophysical Chemistry 105:23-28.
• Högback S, Leppimäki P, Rudnäs B, Björklund S, Slotte JP & Törnquist K. (2003) Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells. Evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. Biochem J 370:111-119.
• Ikonen T, Kainov D, Timmins P, Serimaa R & Tuma R. (2003) Locating the minor components of dsRNA bacteriophage Phi6 by neutron scattering, J Appl Cryst. 36:525-529.
• Jaatinen T, Lahti M, Ruuskanen O, Kinos R, Truedsson L, Lahesmaa R & Lokki M-L. (2003) C4B defiency due to gene deletions and gene conversions associated with severe and chronic infections. Clin Diagn Lab Immunol.10:195-201.
• Jansèn T, Kidron H, Soitamo A, Salminen T & Mäenpää P. (2003)Transcriptional regulation and structural modeling of the Synechocystis sp. PCC 6803 carboxyl-terminal endoprotease family. FEMS Micro Lett. 228:121-128.
• Jansson A, Niemi J, Mäntsälä P & Schneider G. (2003) Crystallization and preliminary X-ray diffraction studies on aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase from Streptomyces purpurascens Acta Crystallogr. D Biol. Crystallogr. 59(Pt 9):1637-9.
• Jansson A, Niemi J, Mäntsälä P & Schneider G. (2003) Crystal structure of aclacinomycin methylesterase with bound product analoques: implications for anthracycline recognition and mechanism J. Biol. Chem. 278(40):39006-13.
• Jansson A, Niemi J, Lindqvist Y, Mantsala P & Schneider G. (2003) Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosyl-L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens. J Mol Biol. 21;334(2):269-80.
• Johnson MS & Tuckwell D. (2003) Evolution of Integrin I-domains: I domains in Integrins, D Gullberg, ed., Landes Bioscience, Texas, USA, pp.1-26.
• Jyrkkärinne J, Mäkinen J, Gynther J, Savolainen H, Poso A & Honkakoski P. (2003) Molecular Determinants of Steroid Inhibition for Constitutive Androstane Receptor CAR. J. Med. Chem.46:4687-4695.
• Kainov DE, Butcher SJ, Bamford DH & Tuma R. (2003) Conserved intermediates on the assembly pathway of dsRNA bacteriophages. J. Mol. Biol. 328:791-804.
• Kainov DE, Pirttimaa M, Tuma R, Butcher SJ, Thomas GJ, Bamford DH & Makeyev EV. (2003) RNA packaging device of dsRNA bakteriophages: Possibly as simple as hexamer of P4 protein. J. Biol. Chem. 278:48084-48091.
• Kajander T. (2003) Structural evolution of Function and stability in muconate lactonizing enzymes. Dissertationes Biocentri Viikki Universitatis Helsingiensis (No. 5/2003) University of Helsinki. (Dissertation)
• Kajander T, Lehtiö L, Schlömann M & Goldman A. (2003) The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function. Prot Sci 12:1855-1864.
• Karjalainen M, Reinikainen M, Lindvall F, Spoof L & Meriluoto JAO. (2003) Uptake and accumulation of dissolved, radiolabeled nodularin in Baltic Sea zooplankton - Environmental Toxicology 18:52-60.
• Karlsson K, Sipiä V, Kankaanpää H & Meriluoto J. (2003) Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders - Journal of Chromatography B 784:243-253.
• Karlsson K, Sipiä V, Krause E, Meriluoto J & Pflugmacher S. (2003) Mass spectrometric detection and quantitation of nodularin-R in flounder livers. Environmental Toxicology 18: 284 - 288.
• Kaski S, Nikkilä J, Oja M, Venna J, Törönen P. & Castrén E. (2003)  Trustworthiness and metrics in visualizing similarity of gene expression BMC Bioinformatics 4:48.
• Kaukinen U, Venäläinen T, Lönnberg H & Peräkylä M. (2003) The base sequence dependent flexibility of linear single-stranded oligoribonucleotides correlates with the reactivity of the phosphodiester bond. Org. Biomol. Chem. 1:2439-2447.
• Korhonen S-P, Tuppurainen K, Laatikainen R & Peräkylä M.(2003) "FLUFF-BALL, A Template-Based Grid-Independent Superposition and QSAR Technique: Validation Using a Benchmark Steroid Data Set." J. Chem. Inf. Comput. Sci. 43:1780- 1793
• Laaksonen K, Junikka M, Lahesmaa R, Terho EO & Savolainen J. (2003) In vitro allergen-induced mRNA expression of SLAM (signaling lymphocytic activation molecule) by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy. J. Allergy Clin Immunol. 112(6):1171-7.
• Laitinen OH, Nordlund HR, Hytönen VP, Uotila STH, Marttila AT, Airenne KJ, Livnah O, Bayer EA, Wilchek M & Kulomaa MS. (2003) Rational design of an active avidin monomer, J Biol Chem. 278:4010-4014.
• Laitinen T, Rouvinen J & Peräkylä M. (2003) "MM-PBSA Free Energy Analysis of endo-1,4-Xylanase II (XynII) - Substrate Complexes: Binding of the Reactive Sugar in a Skew-Boat and Chair Conformation." Org. Biomol. Chem. 1:3535-3540.
• Lehtiö J, Sugiyama J, Gustavsson M, Fransson L, Linder M, & Teeri TT. (2003) The binding specificity and affinity determinants of family 1 and family 3 cellulose binding modules. Proc. Natl. Acad. Sci. 100, 484-489.
• Lehtonen A, Lund R, Saraneva T, Lahesmaa R, Julkunen I & Matikainen S. (2003) IFN-alpha and IL-12 induce IFN regulatory factor 1 (IFR-1), IFR-4, and IFR-8 gene expression in human NK and T cells. Cytokine24(3):81-90
• Lehtovuori P, Mattila K, Nyrönen T, Raaska T, Runeberg N & Tervo A. (2003) Kemian tietokantaopas 2. painos. 86 sivua
• Lehtovuori P & Nyrönen T. (2003) Development of a structure-based molecular discovery environment, CSC Report on Scientific Computing 2001-2003, CSC - Center for Scientific Computing, Espoo, pp. 99-102.
• Lindholm T, Vesterkvist P, Spoof L, Lundberg-Niinistö C & Meriluoto J. (2003) Microcystin occurrence in lakes in Åland, SW Finland - Hydrobiologia 505: 129-138.
• Louhivuori M, Pääkkönen K, Fredriksson K, Permi P, Lounila J & Annila A. (2003) On the origin of residual dipolar couplings from denatured proteins. J Am Chem Soc125(50):15647-15650.
• Louis M, Holm L, Sanchez L & Kaufman M. (2003) A theoretical model for the regulation of Sex-lethal, a gene that controls sex determination and dosage compensation in Drosophila melanogaster. Genetics 165:1355-1384.
• Lucas G, Hendolin P, Harkany T, Agerman K, Paratcha G, Holmgren C, Zilberter Y, Sairanen M, Minichiello L, Castrén E & Ernfors P. (2003) Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia. Nat Neurosci. 6:221-2.
• Lund R, Aittokallio T, Nevalainen O & Lahesmaa R.(2003) Identification of novel genes regulated by IL-12, IL-4 and TGFb during the early polarization of CD4+ lymphocytes. J. Immunol. 171:5328-5336.
• Lund RJ, Ylikoski E, T Aittokallio T, Nevalainen O & Lahesmaa R. (2003) Kinetics and Stat4 or Stat6 mediated regulation of key genes implicated in the polarization of Th1 and Th2 cells. Eur. J. Immunol. 33: 1105-1116.
• Mancini EJ, Grimes JM, Malby R, Sutton GC, Kainov DE, Juuti JT, Makeyev EV, Tuma R, Bamford DH & Stuart DI. (2003) Order and disorder in crystals of hexameric NTPases from dsRNA bacteriophages. Acta Cryst. D 59:2337-2341.
• Marttila AT, Hytönen VP, Laitinen OH, Bayer EA, Wilchek M & Kulomaa MS. (2003) Mutation of important Tyr-33 of chicken avidin: Functional and structural consequences. Biochem. J.369:249-254.
• Merckel MC, Tanskanen J, Edelman S, Westerlund-Wikström B, Korhonen TK & Goldman A. (2003) The structural basis of receptor-binding by Escherichia coli associated with diarrhea and septicemia. J Mol Biol. 331:897-905.
• Mikhailov AD, Härmälä-Braskén A-S, Hellman J, Meriluoto J & Eriksson JE. (2003) Identification of ATP-synthase as a novel intracellular target for microcystin-LR - Chemico-Biological Interactions 142: 223-237.
• Nordlund HR, Laitinen OH, Uotila STH, Nyholm T, Hytönen VP, Slotte JP & Kulomaa MS.(2003) Enhancing the thermal stability of avidin - introduction of disulphide bridges to subunit interfaces, J Biol Chem. 278:2452-2460.
• Nordlund HR, Hytönen VP, Laitinen OH, Uotila STH, Niskanen EA, Savolainen J, Porkka E & Kulomaa MS. (2003) Introduction of histidines into subunit interfaces of avidin allows pH dependent regulation of its quaternary structure and biotin binding, FEBS Lett. 555, 494-454.
• Nordman N, Valjakka J & Peräkylä M. (2003) An Analysis of the Binding Energies of Testosterone, 5-Dihydrotestosterone, Androstenedione and Dehydroepiandrosterone Sulfate with an Anti-Testosterone Antibody. Proteins 50:135-143.
• Nummelin H, Merckel MC, el Tahir Y, Ollikka P, Skurnik M & Goldman A. (2003) Structural studies of Yersinia adhesin YadA. Adv Exp Med Biol 529:85-88.
• Nyholm T, Nylund M, Söderholm A & Slotte JP. (2003) Properties of palmitoyl phosphatidylcholine, sphingomyelin, and dihydrosphingomyelin bilayer membranes as reported by different fluorescent reporter molecules. Biophys J 84:987-997.  
• Nyholm T, Nylund M & Slotte JP. (2003) A Calorimetric Study of Binary Mixtures of Dihydrosphingomyelin and Sterols, Sphingomyelin or Phosphatidylcholine. Biophys J 84:3138-3146.
• Nyholm Thomas. (2003) Membrane Properties of Sphingomyelins and Phosphatidylcholines. Department of Biochemistry and Pharmacy, Åbo Akademi University. (Dissertation)
• Nymalm Y, Kidron H, Söderholm A, Viitanen L, Kaukonen K, Pihlavisto M, Smith D, Veromaa T, Airenne TT, Johnson MS & Salminen TA. (2003) Crystallization and preliminary x-ray analysis of the human vascular adhesion protein-1. Acta Crystallogr. D 59:1288-1290.
• Ollila J & Vihinen M. (2003) Stimulation-induced Gene Expresssion in Ramos B Cells. Genes Immun. 4:343-350.
• Paananen A, Vuorimaa E, Torkkeli M, Penttilä M, Kauranen M, Ikkala O, Lemmetyinen H, Serimaa R & Linder M. (2003) Structural hierarchy in molecular films of two class II hydrophobins. Biochemistry. 42:5253-5258.
• Pasternack A, Coleman SK, Féthière J, Madden DR, LeCaer J-P, Rossier J, Pasternack M & Keinänen K. (2003) Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain. J. Neurochem. 84:1184-1192.
• Pazy Y, Eisenberg-Domovich Y, Laitinen OH, Kulomaa MS, Bayer EA, Wilchek M & Livnah O. (2003) Dimer-tetramer transition between solution and crystalline states of streptavidin and avidin mutants, J. Bacteriol. 185:4050-4056.
• Peltonen JM, Nyrönen T, Wurster S, Pihlavisto M, Hoffrén A-M, Marjamäki A, Xhaard H, Kanerva L, Savola J-M, Johnson MS & Scheinin M. (2003). Effects of Cys/Ser201, Ser/Cys200 and Ser/Cys204 amino acid substitutions in transmembrane domain 5 on Alpha-2A-adrenoceptor activation. Brit. J. Pharmacol. 140:347-358.
• Pentikäinen OT, Settimo L, Keinänen K & Johnson MS. (2003) Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2-alpha,3-beta,4-beta)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacidic acid (kainate) receptors: a molecular modeling study. Biochemical Pharmacology. 66:2413-2425.
• Pentikäinen Olli (2003) Modeling of protein-ligand interactions:Integrin I-domains and ionotropic glutamate receptors. Department of Biochemistry and Pharmacy, Åbo Akademi University. (Dissertation)
• Pääkkönen Kimmo (2003) Applications of residual dipolar coulpings in structural studies of proteins. Division of Biochemistry, Department of Biosciences, Faculty of Sciene, University of Helsinki. (Dissertation)
• Rahnasto M, Raunio H, Poso A & Juvonen RO. (2003) More Potent Inhibition of Human CYP2A6 than Mouse CYP2A5 Enzyme Activities by Derivatives of Phenylethylamine and Benzaldehyde. Xenobiotica. 33:529-39.
• Rantanen VV, Gyllenberg M, Koski K & Johnson MS. 2003. A Bayesian molecular interaction library. J Comp. Aided Mol. Design. 17:435-461.
• Rosengren A, Salmi J, Aittokallio T, Westerholm J, Lahesmaa R, Nyman TA & Nevalainen O. (2003) Comparison of PDQuest and Progenesis software packages in the quantitative analysis of two-dimensional electrophoresis gels. Proteomics 3:1936-46.
• Saarelainen T, Hendolin P, Koponen E, Lucas G, MacDonald E, Agerman K, Haapasalo A, Nawa H, Ernfors P, Aloyz R & Castrén E. (2003) Activation of the trkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci. 23:349-357.
• Sen S, Jaakola V-P, Heimo H, Engström M, Larjomaa P, Lundström K, Scheinin M & Goldman A. (2003) Functional Expression and Direct Visualization of the human alpha 2B-Adrenergic Receptor and alpha 2B-AR -Green Fluorescent Fusion Protein in Mammalian Cell Lines using Semliki Forest Virus Vectors. Protein Express Purif 32(2):265-275.
• Serimaa R, Torkkeli M, Paananen A, Linder M, Kisko K, Knaapila M, Ikkala O, Vuorimaa E, Lemmetyinen H & Seeck O. (2003) Self-assembled structures of hydrophobins HFBI and HFBII, J. Appl. Cryst. 36:499-502.
• Soini AE, Kuusisto A, Meltola NJ, Soini E & Seveus L. (2003) A new technique for multiparameter imaging microscopy: Use of long decay time photoluminescent labels enables multiple color immunocytochemistry with low channel-to-channel crosstalk. Microscopy Research and Technique 62:396-407.
• Soini AE, Yashunsky DV, Meltola NJ & Ponomarev GV. (2003) Influence of linker unit on performance of palladium(II) coproporphyrin labelling reagent and its bioconjugates. Luminescence 18:182-192.
• Sorsa Tia (2003) The Interaction of the Calcium Sensitiser Levosimendan with Cardiac Troponin C. NMR Laboratory, Institute of biotecnology, University of Helsinki. (Dissertation)
• Spoof L, Vesterkvist P, Lindholm T & Meriluoto J. (2003) Screening for cyanobacterial hepatotoxins, microcystins and nodularin in environmental water samples by reversed-phase liquid chromatography-electrospray ionisation mass spectrometry .Journal of Chromatography A 1020:105-119.
• Spoof L, Klimova S, Mikhailov A, Eriksson JE & Meriluoto J. (2003) Synthesis and rganotropism of 3H-dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin. Toxicon 41:153-162.
• Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD & Acharya KR. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure 11:521-532.
• Tervo AJ, Nyrönen TH, Gynther J & Poso A. (2003) Structure-activity relationship analysis of cyclo-oxygenase-2 (COX-2) inhibitors using CoMFA as a predictive tool, EuroQSAR 2002: Designing Drugs and Crop Protectants: processes, problems and solutions, Editors: Martyn Ford, David Livingstone, John Dearden, Han Van de Waterbeemd, Blackwell Publishing Ltd. pp. 320.
• Tervo AJ, NyrÖnen TH, RÖnkkÖ T & Poso A. (2003) A Structure-Activity Relationship Study of Catechol-O-Methyltransferase Inhibitors Combining Molecular Docking and 3D QSAR Methods. J. Comp. Aid. Mol. Des.17:797-810.
• Tirri M, Vaarno J, Soini JT & Hänninen P. (2003) Low cost lasers challenge ultrafast systems in two-photon excitation applications. Opto-electronics Review 11:39-44.
• Tran SE, Meinander A, Holmström TH, Rivero-Müller A, Heiskanen KM., Linnau EK, Courtney MJ, Mosser DD, Sistonen L & Eriksson JE. (2003) Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis. Cell Death Differ. 10:1137-1147.
• Tossavainen H, Permi P, Annila A, Kilpelainen I & Drakenberg T. (2003) NMR solution structure of calerythrin, an EF-hand calcium-binding protein from Saccharopolyspora erythraea. Eur J Biochem. 270(11):2505-2512.
• Tuukkanen S, Virtanen J, Hytönen VP, Kulomaa MS & Törmä P.(2003) Fabrication nof DNA monolayers on gold substrates and guiding of DNA with electric field, manuscript, Rev. Adv. Mater. Science. 5:228-231.
• Valjakka J & Rouvinen J. (2003) Crystal structure of 20k endoglucanase from Melanocarpus albomyces at 1.8Å resolution. Acta Cryst. D59:765-768.
• Wang S, Chandramouli P, Butcher SJ & Dokland T. (2003) Cleavage leads to expansion of bacteriophage P4 procapsids in vitro. Virology. 314:1-8.
• Vesterkvist PSM. & Meriluoto JAO. (2003) Interaction between microcystins of different hydrophobicities and lipid monolayers. Toxicon 41:349-355.
• Wikström M, Verkhovsky MI & Hummer G. (2003) Water-gated mechanism of proton translocation by cytochrome c oxidase. Biophys.Biochem. Acta, 45238, 1-5.
• Virta P, Holmstrom T, Munter T, Nyholm T, Kronberg L & Sjöholm R. (2003) Fluorescent 7- and 8-methyl etheno derivatives of adenosine and 6-amino-9-ethylpurine: syntheses and fluorescence properties. Nucleosides Nucleotides Nucleic Acids. 22:85-98.
• Väisänen S, Peräkylä M, Kärkkäinen JI, Uskokovic MR & Carlberg C. (2003) Structural Evaluation of the Agonistic Action of a Vitamin D Analog with Two Side Chains Binding to the Nuclear Vitamin D Receptor. Mol Pharmacol, 63:1230-1237.
• Väänänen T, Ikonen T, Jokela K, Serimaa R, Pietilä L &Pehu E. (2003) X-ray scattering study on potato (Solanum tuberosum L.) cultivars during winter storage, Carbohydrate Polymers 54, 499-507.
• Xu L, Benson SD, Butcher SJ, Bamford DH & Burnett RM. (2003) The receptor-binding protein, P2 of PRD1, a virus targeting antibiotic-resistant bacteria, has a novel fold suggesting multiple functions. Structure.11:309-322.
• Yang H, Makeyev EV, Butcher SJ, Gaidelyte A & Bamford DH. (2003) Two distinct mechanisms ensure transcriptional polarity in dsRNA bacteriophages. J Virology 77:1195-1203.
• Zhang W-M, Käpylä J, Puranen JS, Knight CG, Tiger CF, Pentikäinen OT, Johnson MS, Farndale RW, Heino J & Gullberg D. (2003) alpha-11 beta-1 Integrin recognizes the GFOGER sequence in interstitial collagens. J. Biol. Chem. 278:7270-7277.
• Zhou Q, Elzagheid A, Jalava P, Sundfors C, Huang D, Syväoja JE & Collan Y (2003) Highly conserved region of the catalytic subunit of DNA polymerase epsilon in human breast cancer. Experimental Oncology 25: 206-210.