Tommi Nyrönen

31.3.2000
Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku and Center for Scientific Computing, Espoo

Properties and Recognition Mechanisms of Molecules - Targeting Design of New Receptor Ligands

Reviewers:

Professor Matti Hotokka, Åbo Akademi University, Turku

Dr. Mikael Peräkylä, University of Kuopio, Kuopio

Opponent:

Professor Flemming Jorgensen, Royal Danish School of Pharmacy, Copenhagen, Denmark

Custos:

Professor Mark S. Johnson, Department of Biohemistry and Pharmacy, Åbo Akademi University, Turku

Publications:

  1. Nyrönen TH & Suontamo R. (1997). An ab initio MO study of neutral high symmetry C8 clusters. Chem. Phys. Letters 280:227-32.
  2. Airola K, Ratilainen J, Nyrönen T & Rissanen K. (1998). A linear open-chain piperazine-pyridine ligand and its meso-helical Co-complex. Inorganica Chim- ica Acta 277:55-61.
  3. Nyrönen TH, Suontamo R & Pitkänen I. (1999) Why betaine crystallizes in high local Cs symmetry. An ab initio MO and DFT study of anhydrous betaine and betaine monohydrate. Theoret. Chem. Accounts 101:209-14.
  4. Salminen T*, Varis M*, Nyrönen T, Pihlavisto M, Hoffren A-M, Lönnberg T, Marjamäki A, Frang H, Savola J-M, Scheinin M & Johnson MS. (1999) Three-dimensional models of a2A-adrenergic receptor complexes provide a structural explanation for ligand binding. J. Biol. Chem. 274:23405-13.
  5. Pentikäinen O, Hoffren A-M*, Ivaska J*, Käpylä J*, Nyrönen T*, Heino J & Johnson MS. (1999) "RKKH" Peptides from the snake venom metallopro- teinase of Bothrops jararaca bind near the metal ion-dependent adhesion site of the human integrin a2 I-domain. J. Biol. Chem. 274:31493-505.
  6. Nyrönen T, Pihlavisto M, Peltonen JM, Hoffren A-M, Varis M, Salminen T, Wurster S, Marjamäki A, Kanerva L, Laaksonen L, Savola J-M, Scheinin M & Johnson MS. (2001) Molecular mechanism for agonist promoted a2Aadrenoceptor activation by norepinephrine and epinephrine. Mol. Pharm., accepted.
* equal contributions