Tia Sorsa

16.10.2003
Lappeenranta University of Technology

The Interaction of the Calcium Sensitiser Levosimendan with Cardiac Troponin C

Reviewer:

Professor Mark S Johnson, Department of Biochemistry and Pharmacy, Åbo Akademi University, Finland

Opponent:

Professor Flemming Martin Poulsen, Department of Protein Chemistry, Institute of Molecular Biology, University of Copenhagen, Denmark

Custos:

Professor Marianne Nyström, Department of Chemical Technology, Lappeenranta University of Technology, Finland

Publications:

  1. Pääkkönen K, Sorsa T, Drakenberg T, Pollesello P, Tilgmann C, Permi P, Heikkinen S, Kilpeläinen I, Annila A (2000) Conformations of the regulatory domain of cardiac troponin C examined by residual dipolar couplings. European Journal of Biochemistry 267: 6665-6672.
  2. Sorsa T, Heikkinen S, Abbott MB, Abusamhadneh E, Laakso T, Tilgmann C, Serimaa R, Annila A, Roseveaar PR, Drakenberg T, Pollesello P, Kilpeläinen I (2001) Binding of levosimendan, a calcium sensitizer, to cardiac troponin C. Journal of Biological Chemistry. 276: 9337-9343.
  3. Sorsa T, Pollesello P, Rosevear PR, Drakenberg T, Kilpeläinen I (2003) Stereoselective binding of levosimendan to cardiac troponin C causes calcium sensitization. European Journal of Pharmacology. Submitted.
  4. Sorsa T, Pollesello P, Permi P, Drakenberg T, Kilpeläinen I (2003) Interaction of levosimendan with cardiac troponin C in the presence of cardiac troponin I peptides. Journal of Molecular and Cellular Cardiology 35: 1055-1061.