Terhi Oja

7.12.2012

Department of Biochemistry and Food Chemistry, University of Turku

Biosynthesis of pyranonaphthoquinone polyketides: characterization of the alnumycin pathway

Reviewers:

Professor Kaarina Sivonen, Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland

Docent Tuomo Glumoff, Department of Biochemistry, University of Oulu, Oulu, Finland

Opponent:

Professor Thomas J. Simpson, School of Chemistry, University of Bristol, Bristol, UK

Custos:

Professor Emeritus Pekka Mäntsälä, Department of Biochemistry and Food Chemistry, University of Turku

Publications:

  1. Oja T, Palmu K, Lehmussola H, Leppäranta O, Hännikäinen K, Niemi J, Mäntsälä P, Metsä-Ketelä M. (2008) Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis. Chem Biol. 15:1046-1057
  2. Grocholski T, Oja T, Humphrey L, Mäntsälä P, Niemi J, Metsä-Ketelä M. (2012) Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis. J Bacteriol. 194:2829-36
  3. Oja T, Klika KD, Appassamy L, Sinkkonen J, Mäntsälä P, Niemi J, Metsä-Ketelä M. (2012) Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage. Proc Natl Acad Sci U.S.A. 109:6024-6029
  4. Oja T, Niiranen L, Sandalova T, Klika KD, Niemi J, Mäntsälä P, Schneider G, Metsä-Ketelä M. (2013) Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Proc Natl Acad Sci U.S.A. 110:1291-1296