Piia Karisola

18.12.2004
Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä

Immunological characterization and engineering of the major latex allergen, hevein (Hev b 6.02)

Reviewers:

Professor (emeritus) Rauno Mäntyjärvi, Department of Clinical Microbiology, University of Kuopio, Kuopio

Professor Jorma Palvimo, Department of Medical Biochemistry, University of Kuopio, Kuopio

Opponent:

Professor Rob C. Aalberse, Sanquin Research at CLB, Amsterdam, Netherlands

Custos:

Professor Markku Kulomaa, Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä

Publications:

  1. Karisola P, Alenius H, Mikkola J, Kalkkinen N, Helin J, Pentikäinen OT, Repo S, Reunala T, Turjanmaa K, Johnson MS, Palosuo T, Kulomaa MS.(2002) The major conformational IgE-binding epitopes of hevein (Hev b6.02) are identified by a novel chimera-based allergen epitope mapping. J Biol Chem. 277:22656-61.
  2. Karisola P, Mikkola J, Kalkkinen N, Airenne KJ, Laitinen OH, Repo S, Pentikäinen OT, Reunala T, Turjanmaa K, Johnson MS, Palosuo T, KulomaaMS & Alenius H. (2004) Construction of Hevein (Hev b 6.02) with Reduced Allergenicity for Immunotherapy of Latex Allergy by Comutation of Six Amino Acid Residues on the Conformational IgE Epitopes, revised version, J. Immunol. 172:2621-2628.
  3. Karisola P, Kotovuori A, Poikonen S, Niskanen E, Kalkkinen N, Turjanmaa K, Palosuo T, Reunala T, Alenius H & Kulomaa MS. (2004) Isolated hevein-like domains but not 31 kD endochitinases are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit sundrome. J Allergy Clin Immunol. (in press)