Pekka Postila

27.11.2010
Nanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä

Dynamics of the Ligand-Binding Domains of Ionotropic Glutamate Receptors

Reviewers:

Dr. André H. Juffer, Biocenter Oulu and Department of Biochemistry, University of Oulu, Oulu, Finland

Professor Kari Keinänen, Viikki Biocenter, Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland

Opponent:

Mikael Peräkylä, PhD Adjuct Professor, Department of Biosciences, University of Eastern Finland, Kuopio Campus

Custos:

Adjunct Professor Olli Pentikäinen, Department of Biological and Environmental Science, University of Jyväskylä

Publications:

  1. Lash LL, Sanders JM, Akiyama N, Shoji M, Postila P, Pentikäinen OT, Sasaki M, Sakai R, Swanson GT. (2008) Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors. J Pharmacol Exp Ther. Feb;324(2):484-96. Epub 2007 Nov 21.
  2. Frydenvang K, Lash LL, Naur P, Postila PA, Pickering DS, Smith CM, Gajhede M, Sasaki M, Sakai R, Pentikaïnen OT, Swanson GT, Kastrup JS. (2009) Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. J Biol Chem. May 22;284(21):14219-29. Epub 2009 Mar 18.
  3. Postila PA, Swanson GT, Pentikäinen OT. (2010) Exploring kainate receptor pharmacology using molecular dynamics simulations. Neuropharmacology. Feb;58(2):515-27. Epub 2009 Sep 6.
  4. Lash-Van Wyhe LL, Postila PA, Tsubone K, Sasaki M, Pentikäinen OT, Sakai R, Swanson GT. (2010) Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine. Neuropharmacology. Mar;58(3):640-9. Epub 2009 Dec 4.
  5. Postila PA, Ylilauri M, Pentikäinen OT (2010) Partial Agonism of Ionotropic Glutamate Receptors Indicated by an Interdomain Hydrogen Bond (Submitted)