Pauli Kallio

12.12.2008
Department of Biochemistry and Food Chemistry, University of Turku

Type II Aromatic Polyketide Biosynthetic Tailoring Enzymes: Diversity and Adaptation in Streptomyces Secondary Metabolism

Reviewers:

Professor Pirkko Heikinheimo, Institute of Biotechnology, University of Helsinki

Professor Lloyd Ruddock, Department of Biochemistry, University of Oulu

Opponent:

Professor Gregory L. Challis, Department of Chemistry, University of Warwick, Coventry, United Kingdom

Custos:

Professor Jyrki Heino, Department of Biochemistry and Food Chemistry, University of Turku

Publications:

  1. Sultana A, Kallio P, Jansson A, Wang J-S, Niemi J, Mäntsälä P & Schneider G. (2004) Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis. Acta Crystallogr. D Biol. Crystallogr. 60(Pt 6):1118-2000.
  2. Sultana A, Kallio P, Jansson A, Wang J-S, Niemi J, Mäntsälä P & Schneider G. (2004) Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation EMBO J. 5;23(9):1911-21.
  3. Kallio P, Sultana A, Niemi J, Mantsala P & Schneider G. (2006) Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. J Mol Biol. 357:210-20.
  4. Koskiniemi H, Metsä-Ketelä M, Dobritzsch D, Kallio P, Korhonen H, Mäntsälä P, Schneider G & Niemi J. (2007) Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis. J Mol Biol. 372:633-48.
  5. Kallio P, Liu Z, Mäntsälä P, Niemi J & Metsä-Ketelä M. (2008) A Nested Gene in Streptomyces Bacteria Encodes a Protein Involved in Quaternary Complex Formation. J Mol Biol. 375:1212-1221.
  6. Kallio P, Liu Z, Mäntsälä P, Niemi J & Metsä-Ketelä M. (2008) Sequential action of two flavoenzymes PgaE and PgaM in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C. Chemistry & Biology. 15(2):157-66.