Olli Salin

25.11.2011
Department of Biosciences, Åbo Akademi University, Turku, Finland

Early drug discovery approaches to identify compounds affecting Chlamydia pneumoniae growth and evaluation of their suitability for further drug development.

Reviewers:

Professor Mikael Elofsson, Umeå Center of Microbial Research, University of Umeå, Umeå, Sweden

Professor Seppo Salminen, Functional Foods Forum, University of Turku, Turku Finland

Opponent:

Professor Arto Urtti, Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Custos:

Professor Pia Vuorela, Pharmaceutical Sciences, Department of Biosciences, Åbo Akademi University, Turku, Finland

Publications:

  1. Keurulainen L*, Salin O*, Siiskonen A*, Kern JM, Alvesalo J, Kiuru P, Maass M, Yli-Kauhaluoma J, Vuorela P. (2010) Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae. J Med Chem. 53(21):7664-74.
  2. Salin O, Alakurtti S, Pohjala L, Siiskonen A, Maass V, Maass M, Yli-Kauhaluoma J, Vuorela P. (2010) Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae. Biochem Pharmacol. 80(8):1141-51.
  3. Salin OP, Pohjala LL, Saikku P, Vuorela HJ, Leinonen M, Vuorela PM. (2011) Effects of coadministration of natural polyphenols with doxycycline or calcium modulators on acute Chlamydia pneumoniae infection in vitro. J Antibiot (64(11):747-52
  4. Salin O, Törmäkangas L, Leinonen M, Saario E, Hagström M, Ketola RA, Saikku P, Vuorela H, Vuorela PM. (2011) Corn Mint ( Mentha arvensis ) Extract Diminishes Acute Chlamydia pneumoniae Infection in Vitro and in Vivo. J Agric Food Chem. 2011 Nov 22. [Epub ahead of print]
  5. Salin O, Donath O, Ladurner A, Vuorela P, Dirsch V, Reznieck G, Vuorela P. Ethyl gallate from red wine inhibits Chlamydia pneumoniae independetly from eNOS expression. (Submitted)

(*) Equal contribution

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