Olli Pentikäinen

10.10.2003
Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku

Modeling of protein-ligand interactions: Integrin I-domains and ionotropic glutamate receptors

Reviewers:

Ph.D. Michael Courtney, University of Kuopio, Finland

Ph.D. André Juffer, University of Oulu, Finland

Opponent:

Ph.D. John P. Overington MRSC C.Chem., Inpharmatica, UK

Custos:

Professor Mark S. Johnson, Dept. of Biochemistry and Pharmacy, Åbo Akademi University, Turku, Finland

Publications:

  1. Lampinen M, Pentikäinen O, Johnson MS and Keinanen K. AMPA receptors and bacterial periplasmic amino acid-binding proteins share the ionic mechanism of ligand recognition. EMBO Journal, 1998, volume 17, pages: 4704-4711.
  2. Pentikäinen OT, Settimo L, Keinänen K and Johnson MS. Selective agonist binding of AMPA and kainate receptors. Biochemical Pharmacology, in press.
  3. Jouppila A, Pentikäinen OT, Settimo L, Nyrönen T, Haapalahti J-P, Lampinen M, Mottershead D, Johnson MS and Keinänen K. Determinants of antagonist binding at the a-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid receptor: Role of the conserved Arg-507 and Glu-727 residues. European Journal of Biochemistry, 2002, volume 269, pages: 6261-6270.
  4. Pentikäinen O, Hoffrén A-M*, Ivaska J*, Käpylä J*, Nyrönen T*, Heino J and Johnson MS. RKKH peptides from the snake venom metalloproteinase of Bothrops jararaca bind near the MIDAS site of the human integrin a2 I-domain. Journal of Biological Chemistry, 1999, volume 274, pages: 31493-31505. (*Equal contribution to the work).
  5. Tulla M, Pentikäinen OT, Viitasalo T, Käpylä J, Impola U, Nykvist P, Nissinen L, Johnson MS and Heino J. Selective binding of collagen subtypes by integrin a1I, a2I and a10I domains. Journal of Biological Chemistry, 2001, volume 276, pages: 48206-48212.