Michael P. Okoh

22.11.2002
Department of Biosciences, Division of Biochemistry, University of Helsinki

Molecular and biophysical analysis of the non-catalytic PH, TH, SH4 and SH2 domains of Bruton tyrosine kinase (Btk) protein

Reviewers:

Professor Veli-Pekka Lehto, Department of Pathology, Haartman Institute, University of Helsinki, Helsinki

Professor Dennis Bamford, Deparment of Biosciences, Division of Genetics, University of Helsinki, Helsinki

Opponent:

Professor John E. Eriksson, Department of Biology, Laboratory of Animal Physiology, University of Turku

Custos:

Professor Carl G. Gahmberg, Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki

Publications:

  1. Okoh MP & Vihinen M. (1999). Pleckstrin homology domains of Tec family protein kinases. Biochem Biophys Res Comm. 265:151-157
  2. Okoh MP & Vihinen M. (2002) Interaction between Btk TH and Sh4 domain. Biopolymers. 63:325-334
  3. Okoh MP, Kainulainen L, Heiskanen K, Nizam Isa M, Varming K, Ruuskainen O & Vihinen M. (2002) Novel Insertions of Bruton Tyrosine Kinase in Patients with X-linked Agammaglobulinemia. Human mutat.DOI 10, 1002/humu
  4. Hansson H, Okoh MP, Smith CIE, Vihinen M & Härd T. (2001) Intermolecular interactions between the Sh4 domain and the proline-rich TH region of Bruton's tyrosine kinase. FEBS Lett. 489:67-70
  5. Okoh MP, Lappalainen I, Stenberg K, Pasanen T & Vihinen M.(2002) Ligand Binding and Stability of Four N-Terminal Domains of Btk. Manuscript