Jan-Jonas Filén

8.2.2008
Department of Medicinal Biochemistry and Molecular Biology, University of Turku, Turku

Quantitative proteomics in the characterization of T helper lymphocyte differentiation

Reviewers:

Professor Seppo Auriola, Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio

Docent Panu Kovanen, Haartman Institute, Department of Pathology, University of Helsinki, Helsinki

Opponent:

Professor Ruedi Aebersold, Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich and Faculty of Science, University of Zürich, Zürich, Switzerland

Custos:

Professor Riitta Lahesmaa, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku

Publications:

  1. Filén J-J*, Nyman T*, Korhonen J, Goodlett DR & Lahesmaa R. (2005) Characterization of microsomal fraction proteome in human lymphoblasts reveals the down-regulation of galectin-1 by interleukin-12. Proteomics. 5:4719-32.
  2. Filén J-J*, Filén S*, Moulder R, West A, Kouvonen P, Kantola S, Björkman M, Katajamaa M, Rasool O, Nyman TA and Lahesmaa R. Determination of interleukin-4 regulated proteins in the microsomal fraction of CD4+ cells by using isotope-coded affinity tags. (manuscript)
  3. Moulder R, Filén J-J, Salmi J, Katajamaa M, Nevalainen OS, Oresic M, Aittokallio T, Lahesmaa R & Nyman T. (2005) A comparative evaluation of software for the analysis of liquid chromatography-tandem mass spectrometry data from isotope coded affinity tag experiments, Proteomics. 5:2748-2760.
  4. Salmi J, Moulder R, Filen JJ, Nevalainen OS, Nyman TA, Lahesmaa R & Aittokallio T. (2006) Quality classification of tandem mass spectrometry data. Bioinformatics. 22:400-6.
    5. * equal contribution