Henri Xhaard

21.06.2006
Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku

Adrenoceptors: Evolution, Structure Modeling and Ligand Recognition

Reviewers:

Professor Reijo Lahti, Department of Biochemistry, University of Turku, Turku

Professor Antti Poso, Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio

Opponent:

Professor Marcel Hibert, Département de Pharmacochimie de la Communication Cellulaire, Institut Gilbert Laustriat, Faculté de Pharmacie de Strasbourg, Illkirch, France

Custos:

Professor Mark S. Johnson, Department of Biochemistry and Pharmacy, Åbo Akademi University, Turku

Publications:

  1. Ruuskanen J, Xhaard H, Marjamäki A, Salaneck E, Salminen T, Yan Y-L, Postlethwait JH, Johnson MS, Larhammar D & Scheinin M. (2004) Identification of duplicated fourth alpha-2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol. Biol. Evol. 21:14-28.
  2. Ruuskanen JO, Laurila J, Xhaard H, Rantanen V-V, Vuoriluoto K, Wurster S, Marjamäki A, Vainio M, Johnson MS & Scheinin M. (2005) Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha-2-adrenergic receptors. Brit J Pharm. 144:165-177.
  3. Xhaard H, Nyrönen T, Rantanen V-V, Ruuskanen J O, Laurila J, Salminen T, Scheinin M, and Johnson M S. (2005) Model structures of alpha-2 adrenoceptors in complex with automatically docked antagonist ligands raise the possibility of interactions dissimilar from agonist ligands. J Struct Biol. 150:126-143.
  4. Xhaard H, Rantanen V-V, Nyrönen T and Johnson M S. (2006) Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines. J Med Chem. 49: 1706-1719.