Heikki Takala

09.12.2011
Department of Biologial and Envirmonmental Sciences, University of Jyväskylä, Jyväskylä, Finland

Three Proteins Regulating Integrin Function - Filamin, 14-3-3 and RIAM

Reviewers:

Professor Jyrki Heino, Department of Biochemistry and Food Chemistry, Turku, Finland

Assistant Professor Inari Kursula, Centre for Structural Systems Biology at DESY; Helmholtz Centre for Infection Research and University of Hamburg Hamburg, Germany and Department of Biochemistry, University of Oulu, Oulu, Finland

Opponent:

Associate Professor David A. Calderwood, Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA

Custos:

Professor Jari Ylänne, Department of Biologial and Environmental Sciences, University of Jyväskylä, Jyväskylä, Finland

Publications:

  1. Takala H. & Ylänne J. (2011) Binding Properties and Stability of the Rasassociation Domain of Rap1-GTP Interacting Adapter Molecule (RIAM). (Submitted)
  2. Pentikäinen U, Jiang P, Takala H, Ruskamo S, Campbell ID & Ylänne J. (2011) Assembly of a Filamin Four-domain Fragment and the Influence of Splicing Variant-1 on the Structure. Journal of Biological Chemistry 286: 26921-26930.
  3. Takala H,* Nurminen E,* Nurmi SM,* Aatonen M, Strandin T, Takatalo M, Kiema T, Gahmberg CG, Ylänne J & Fagerholm SC. (2008) Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding. Blood 112: 1853-1862.
* Equal contribution