Elisa Nurminen

15.04.2011
Nanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä

Rational Drug Discovery - Structural Studies of Protein-Ligand Complexes

Reviewers:

Professor Jyrki Kukkonen, Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki

Adjunct Professor Maija Lahtela-Kakkonen, Department of Pharmaceutial Chemistry, University of Eastern Finland, Kuopio Campus

Opponent:

Professor Mark S. Johnson, Department of Biosciences, Biochemistry, Åbo Akademi University

Custos:

Adjunct Professor Olli Pentikäinen, Department of Biological and Environmental Science, University of Jyväskylä

Publications:

  1. Nurminen EM, Pihlavisto M, Lázár L, Szakonyi Z, Pentikäinen U, Fülöp F, Pentikäinen OT. (2010) Synthesis, in vitro activity, and three-dimensional quantitative structure-activity relationship of novel hydrazine inhibitors of human vascular adhesion protein-1. J Med Chem. Sep 9;53(17):6301-15.
  2. Nurminen EM, Pihlavisto M, Lazar L, Pentikäinen U, Fulop F, Pentikäinen OT. (2011) Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors. J Med Chem. Apr 14;54(7):2143-2154.
  3. Playford MP, Nurminen E, Pentikäinen OT, Milgram SL, Hartwig JH, Stossel TP, Nakamura F. (2010) Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A. J Biol Chem. May 28;285(22):17156-65.
  4. Nurminen EM, Mattila E, Ylilauri M, Määttä J, Pentikäinen U, Ivaska J & Pentikäinen OT (2010) Mitoxantrone activates T-cell protein tyrosine phosphatase (TCPTP) via bindng to a hydrophobic groove. (Submitted)