Denis Kainov

04.11.2005
Department of Biological and Environmental Sciences, University of Helsinki, Helsinki

Packaging Motors of Cystoviruses

Reviewers:

Docent Mikko Frilander, University of Helsinki, Helsinki

Docent Alexander Plyusnin, University of Helsinki, Helsinki

Opponent:

Professor John Walker, Medical Research Council, Dunn Human Nutrition Unit, Cambridge, United Kingdom

Custos:

Professor Tapio Palva, University of Helsinki, Helsinki

Publications:

  1. Kainov DE, Butcher SJ, Bamford DH & Tuma R. (2003) Conserved intermediates on the assembly pathway of dsRNA bacteriophages. J. Mol. Biol. 328:791-804.
  2. Kainov DE, Pirttimaa M, Tuma R, Butcher SJ, Thomas GJ, Bamford DH & Makeyev EV. (2003) RNA packaging device of dsRNA bakteriophages: Possibly as simple as hexamer of P4 protein. J. Biol. Chem. 278:48084-48091.
  3. Kainov DE, Lísal J, Bamford DH & Tuma R. (2004) Packaging motor from double-stranded RNA bacteriophage phi12 acts as an obligatory passive conduit during transcription. Nucl Acid Res 32:3515-21.
  4. Mancini EJ, Kainov DE, Grimes JM, Tuma R, Bamford DH & Stuart DI. (2004) Atomic Snapshots of an RNA Packaging Motor Reveal Conformational Changes Linking ATP Hydrolysis to RNA Translocation. Cell 118:743-755.
  5. Lísal J, Lam T, Kainov DE, Emmett MR, Marshall AG & Tuma R. (2005) Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states. Nat. Struct. Mol. Biol. 12: 460-466.
  6. Kainov DE, Mancini EJ, Lisal J, Grimes JM, Bamford DH, Stuart DI & Tuma R. (2005) Structural basis of mechanochemical coupling in hexameric packaging motors. Manuscript.