Anni Kauko

19.1.2007
Department of Biochemistry and Food Chemistry, University of Turku, Turku

Iron and oxidative stress: Structural studies on Dps-like peroxide resistance protein (Dpr) from Streptococcus suis

Reviewers:

Professor Salam al-Karadaghi, Department of Molecular Biophysics, Centre for Chemistry and Chemical Engineering, Lund University, Lund, Sweden

Docent Roman Tuma, Department of Biosciences, Institute of Biotechnology, University of Helsinki, Helsinki

Opponent:

Professor Demetrius Tsernoglou, Department of Biochemical Sciences, University of Rome, Rome, Italy

Custos:

Professor Reijo Lahti, Department of Biochemistry and Food Chemistry, University of Turku, Turku

Publications:

  1. Haataja S, Penttinen A, Pulliainen A, Tikkanen K, Finne J & Papageorgiou AC. (2002) Expression, purification and crystallisation of Dpr, a ferritin-like protein from the Gram-positive meningitis-associated bacterium Streptococcus suis. Acta Cryst. D 58:1851-1853.
  2. Kauko A, Haataja S, Pulliainen AT, Finne J & Papageorgiou AC. (2004) Crystal structure of Streptococcus suis Dps-like peroxide resistance protein Dpr: Implications for iron incorporation. J Mol Biol 338:547-558.
  3. Pulliainen AT, Kauko A, Haataja S, Papageorgiou AC & Finne J. (2005) Dps/Dpr ferritin-like protein: Insights into the mechanism of iron incorporation and evidence for a central role in cellular iron homeostasis. Mol Microbiol. 57:1086-1100.
  4. Kauko A, Pulliainen AT, Haataja S, Meyer-Klaucke W, Finne J & Papageorgiou AC. (2006) Iron incorporation in Streptococcus suis Dps-like peroxide resistance protein Dpr requires mobility in the ferroxidase centre and leads to the formation of a ferrihydrite-like core. J Mol Biol. 364:97-109.